@article {905961,
	title = {The genome of a songbird},
	journal = {Nature},
	volume = {464},
	number = {7289},
	year = {2010},
	note = {<p>577EOTimes Cited:27Cited References Count:35</p>},
	month = {Apr 1},
	pages = {757-762},
	abstract = {<p>The zebra finch is an important model organism in several fields(1,2) with unique relevance to human neuroscience(3,4). Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented only in humans and a few other animals and lacking in the chicken(5)-the only bird with a sequenced genome until now(6). Here we present a structural, functional and comparative analysis of the genome sequence of the zebra finch (Taeniopygia guttata), which is a songbird belonging to the large avian order Passeriformes(7). We find that the overall structures of the genomes are similar in zebra finch and chicken, but they differ in many intrachromosomal rearrangements, lineage-specific gene family expansions, the number of long-terminal-repeat-based retrotransposons, and mechanisms of sex chromosome dosage compensation. We show that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets. We also show evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience. These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour.</p>},
	keywords = {Brain, chicken, dosage compensation, Evolution, gene-expression, learned birdsong, mechanisms, Nucleus, reveals, RNA},
	isbn = {0028-0836},
	author = {Warren, W. C. and Clayton, D. F. and Ellegren, H. and Arnold, A. P. and Hillier, L. W. and Kunstner, A. and Searle, S. and White, S. and Vilella, A. J. and Fairley, S. and Heger, A. and Kong, L. S. and Ponting, C. P. and Jarvis, E. D. and Mello, C. V. and Minx, P. and Lovell, P. and Velho, T. A. F. and Ferris, M. and Balakrishnan, C. N. and Sinha, S. and Blatti, C. and London, S. E. and Li, Y. and Lin, Y. C. and George, J. and Sweedler, J. and Southey, B. and Gunaratne, P. and Watson, M. and Nam, K. and Backstrom, N. and Smeds, L. and Nabholz, B. and Itoh, Y. and Whitney, O. and Pfenning, A. R. and Howard, J. and Voelker, M. and Skinner, B. M. and Griffin, D. K. and Ye, L. and McLaren, W. M. and Flicek, P. and Quesada, V. and Velasco, G. and Lopez-Otin, C. and Puente, X. S. and Olender, T. and Lancet, D. and Smit, A. F. A. and Hubley, R. and Konkel, M. K. and Walker, J. A. and Batzer, M. A. and Gu, W. J. and Pollock, D.D. and Chen, L. and Cheng, Z. and Eichler, E. E. and Stapley, J. and Slate, J. and Ekblom, R. and Birkhead, T. and Burke, T. and Burt, D. and Scharff, C. and Adam, I. and Richard, H. and Sultan, M. and Soldatov, A. and Lehrach, H. and Edwards, S. V. and Yang, S. P. and Li, X. C. and Graves, T. and Fulton, L. and Nelson, J. and Chinwalla, A. and Hou, S. F. and Mardis, E. R. and Wilson, R. K.}
}
